PolyPhil™ Polynucleotides: Advanced Skin Regeneration at Hazel Clinic by Dr. Susana Fontana

PolyPhil™ Polynucleotides: A New Era of Skin Regeneration

Hazel Clinic — Led by Dr. Susana Fontana, Medical Doctor

At Hazel Clinic in Blackrock, Dublin, we specialise in regenerative, science-driven skin treatments. One of the most advanced therapies we offer is PolyPhil™ Polynucleotides — a next-generation injectable treatment designed not to fill, but to biostimulate the skin from within.

Unlike traditional dermal fillers, PolyPhil™ does not add volume. Instead, it enhances the skin’s own ability to repair, restructure and regenerate, making it an exceptional option for patients wanting better tone, radiance, elasticity and firmness without altering facial shape.

PolyPhil™ (formerly PhilArt®) is based on PN-HPT™ polynucleotides, long-chain DNA fragments with high purification technology that has over 70 years of scientific research supporting its safety and efficacy.

What Are Polynucleotides?

Polynucleotides are natural DNA fragments—purified and derived from European freshwater fish intended for human consumption. These molecules act as bio-stimulators, improving the skin’s architecture and creating an optimal environment for cellular repair.

They work by:

1. Stimulating Fibroblasts

Fibroblasts produce collagen (firmness), elastin (elasticity) and hyaluronic acid (hydration). Polynucleotides activate these cells to regenerate tissue naturally.

2. Deep Hydration

Polynucleotides bind water in the dermis, improving skin hydration, smoothness and glow.

3. Antioxidant Protection

They capture free radicals responsible for premature ageing.

4. Tissue Repair & Remodeling

Ideal for improving scars, stretch marks, post-blemish marks and sun-damaged skin.

Benefits of PolyPhil™ Polynucleotides

✔ Collagen stimulation

✔ Improved firmness & elasticity

✔ Smoother skin texture

✔ Reduction of fine lines and crepey skin

✔ Deep, long-lasting hydration

✔ Antioxidant and anti-inflammatory properties

✔ Safe for delicate areas (eyes, neck)

✔ Natural, subtle rejuvenation with no volume added

✔ Suitable for all skin types and ages

Patients often notice:

• Fresher, brighter, healthier-looking skin

• Improved tone and texture

• Firmer, more elastic tissue

• More even complexion

• Reduction of tired-looking eyes

• Restored glow and radiance

PolyPhil™ Product Range at Hazel Clinic

We offer the full PolyPhil™ portfolio to tailor treatment to each patient’s needs:

PolyPhil™

For general skin regeneration of the face, neck, décolletage and hands.

Improves hydration, texture, tone and firmness.

PolyPhil™ Eye

A specialised formulation for the delicate periocular area.

Improves:

– Dark circles

– Fine lines

– Puffiness

– Tired-looking eyes

PolyPhil™ Next

Designed for more mature or damaged skin.

Targets:

– Deep dehydration

– Elastosis

– Stretch marks

– Depressed scars

PolyPhil™ Hair

For scalp and eyebrow hair quality improvement.

Supports follicle health and stimulates hair growth.

Who Is PolyPhil™ Suitable For?

PolyPhil™ is ideal for patients who want regenerative, subtle, natural rejuvenation without fillers.

Candidates include:

• Those with visible signs of ageing

• Patients with dull or dehydrated skin

• Individuals with fine lines or crepey skin

• Younger patients wanting prevention

• Mature patients needing structural skin support

• People with stretch marks or scarring

• Individuals seeking under-eye rejuvenation

• Patients who want minimal downtime

Not suitable for:

• Pregnancy or breastfeeding

• Active infection

• Unwell or febrile patients on the day of treatment

How the Treatment Works

Injection Technique

PolyPhil™ is injected intradermally or subcutaneously, depending on the area and indication.

In some cases, a cannula may be used to minimise bruising.

Sessions · Most patients require 2–3 sessions, spaced 2–3 weeks apart.

Duration of Procedure · 10–30 minutes.

Recovery · No downtime. Mild swelling, small bumps (“blebs”), or redness may occur and usually resolve within hours to a few days.

When to Expect Results

Hydration effects: within a few days

Collagen stimulation: from 2–4 weeks

Skin quality improvements: progressive with each session

Longevity: several months, depending on age, lifestyle and skin condition.

PolyPhil™ vs Other Skin Boosting Treatments

PolyPhil™ vs Profhilo

• PolyPhil™: best for texture, tone, delicate areas, collagen stimulation

• Profhilo: best for deep hydration and overall firmness

PolyPhil™ vs Hyaluronic Acid Fillers (e.g., Juvederm)

• PolyPhil™: no volume, improves texture and regeneration

• Fillers: add volume to restore facial contours

PolyPhil™ vs Sunekos

• PolyPhil™: polynucleotides for regeneration

• Sunekos: amino acids + HA for hydration and collagen support

  Both effective for neck and eye areas, each with different mechanisms.

Your Consultation at Hazel Clinic

Every treatment at Hazel Clinic begins with a comprehensive medical consultation with Dr. Susana Fontana.

This includes:

• Analysis of skin quality

• Full medical history

• Assessment of goals and indications

• Personalised treatment mapping

• Discussion of expected outcomes

We believe in a full-face approach that harmonises skin health, structure and luminosity, always prioritising safety and natural-looking results.

What to Expect During & After Treatmen

During

• Topical anaesthetic may be applied • Series of micro-injections with fine needles • Quick and well-tolerated

After

• Mild redness or swelling • Tiny bumps at injection points • No restriction in daily activities

Results

• Natural, progressive improvement • Healthier, firmer, smoother, glowing skin

Conclusion

PolyPhil™ Polynucleotides represent the next generation of regenerative aesthetic medicine, focusing on skin quality from the inside out—without adding volume or altering facial features.

At Hazel Clinic, under the guidance of Dr. Susana Fontana, this treatment is customised to your skin’s biology, ensuring subtle but powerful improvements in firmness, hydration, radiance and overall rejuvenation.