PolyPhil™ Polynucleotides for Collagen Stimulation and Skin Rejuvenation
Advanced Collagen Stimulation & Skin Regeneration
PolyPhil™ is a next-generation regenerative injectable made from purified polynucleotides, designed to enhance skin quality from within. Unlike traditional fillers that add volume, PolyPhil™ works as a biostimulator, helping the skin naturally regenerate collagen, elastin and hyaluronic acid—resulting in improved texture, elasticity, hydration and radiance.
This treatment is ideal for anyone seeking natural rejuvenation without altering facial shape. PolyPhil™ is safe for all skin types and especially effective for delicate areas such as the under-eye.
How PolyPhil™ Works
PolyPhil injectables contain highly purified, long-chain PN-HPT™ polynucleotides, derived from European freshwater fish. Once injected into the skin, they work through four key mechanisms:
Fibroblast activation
Stimulates the cells responsible for the production of collagen and elastin, improving firmness and elasticity.
Deep hydration
Polynucleotides bind water within the dermal layers, creating long-lasting hydration and a smoother surface.
Antioxidant protection
Neutralises free radicals and reduces inflammation, slowing down the ageing process.
Tissue repair
Improves the appearance of scars, sun damage and textural irregularities.
PolyPhil™ Improves texture, hydration and firmness across:
• Face, Neck, Décolletage, Hands
PolyPhil™ Eye
Designed specifically for the delicate eye area:
• Fine lines, Dark circles, Puffiness, Crepey under-eye skin
PolyPhil™ Next
A stronger formulation for mature or damaged skin, ideal for:
• Sun damage, Stretch marks, Depressed or fibrotic scars
PolyPhil™ Hair
Supports scalp and eyebrow regeneration by improving follicle health.
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PolyPhil™ treatments at Hazel Clinic begin with a comprehensive consultation with Dr. Susana Fontana, where your skin quality, concerns and goals are assessed to create a personalised plan.
During the procedure:
• The skin is cleansed and prepared.
• In some areas a topical anaesthetic may be applied for comfort.
• Dr. Fontana injects the polynucleotide gel either intradermally or subcutaneously, depending on the treatment area.
• In delicate areas, such as under the eyes, a cannula may be used to reduce risk of bruising.
A session typically lasts 15–30 minutes. You can resume normal activities immediately after.
Recommended treatment course: 2–3 sessions, spaced 2–3 weeks apart, depending on individual goals and indication.
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Immediately after treatment:
• Mild redness, swelling or small visible bumps (“blebs”) are normal and temporary.
• Sensitive areas such as the eye region may feel slightly tender.
• These effects usually resolve within a few hours to a couple of days.
Results timeline:
• Hydration boost: within a few days
• Texture and radiance: 2–3 weeks
• Collagen synthesis and firmness: progressive improvement over several weeks
• Final outcome: usually visible after completing the full treatment course
PolyPhil™ provides a natural, gradual skin improvement without altering facial structure or adding volume.
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PolyPhil™ is suitable for adults seeking:
• Improved skin texture and tone
• Enhanced firmness and elasticity
• Reduction of fine lines
• Brightening of the under-eye area
• Improved hydration and radiance
• Better appearance of scars or stretch marks
• A regenerative treatment without volume enhancement
Not suitable for:
• Pregnancy or breastfeeding
• Active infection (local or systemic)
• Recent illness, flu, or fever
• Known severe allergies or autoimmune/immune-compromised conditions (requires prior discussion with Dr. Fontana)
• Patients currently unwell on the day of treatment
Your medical history and suitability are always assessed with safety as the top priority.
Please make sure that you are feeling fit and well on the day of your scheduled treatment. We cannot perform the treatment if you are feeling unwell or have recently had an illness, including flu.
Please make sure that you are feeling fit and well on the day of your scheduled treatment. We cannot perform the treatment if you are feeling unwell or have recently had an illness, including flu.
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When will I see results?
Early hydration and glow can appear within days. Structural improvements in collagen and elasticity develop over 2–4 weeks, with best results after completing the recommended sessions.
How long do results last?
Results typically last several months depending on skin quality, age, lifestyle, sun exposure, smoking, stress and internal collagen levels. Maintenance sessions may be recommended.
Does the treatment hurt?
Discomfort is minimal. Many patients describe the injections as light pinches. Topical numbing can be applied if needed, and cannula use reduces discomfort in delicate areas.
Is there downtime?
No downtime is required. Temporary redness or small bumps may appear but settle quickly.
Is PolyPhil™ a filler?
No. PolyPhil™ is a biostimulator, not a volumising filler. It improves the skin’s structure and function rather than adding volume.
Can PolyPhil™ be combined with other treatments?
Yes. It pairs well with anti-wrinkle injections, dermal fillers, toxin botulinum, laser therapies and other skin-quality treatments for a full-face approach.
Is the product safe?
PolyPhil™ polynucleotides are highly purified using PN-HPT™ technology and have a strong safety record supported by decades of clinical research.